Eva Chi

Contact


Phone: (505)-277-2263

Physical Address

Room 2057
Centennial Engineering Center

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Associate Professor

Education

Ph.D. University of Colorado, Chemical Engineering , 2004

M.S. University of Colorado, Chemical Engineering , 2001

B.S. University of California, Berkeley, Chemical Engineering with Biotecnology Emphasis, 1999

B.S. University of California, Berkeley, Chemistry, 1999

Biography

Research

The research in my group focuses on understanding the structure, dynamics, and stability of proteins. Currently, there are three research areas in my group: 1. mechanism of protein misfolding and aggregation in the pathogenesis of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson's disease, 2. dynamics of proteins at interfaces, both artificial and physiological interfaces, and 3. stabilization of proteins for bioengineering applications, including biopharmaceuticals, biosensors, and biofuel cells. We use a wide range of biophysical tools in our research, including static and dynamic light scattering, numerous spectroscopic methods, chromatography, surface characterization techniques, and X-ray and neutron scattering. We apply the fundamentals in thermodynamics, kinetics, transport, and intermolecular and surface interactions to study our systems.

Professional Experience 

  • 2008 - Present: Assistant Professor, Department of Chemical & Nuclear Engineering and Center for Biomedical Engineering • University of New Mexico, Albuquerque, NM
  • 2004 - 08: Postdoctoral Research Fellow, Department of Chemistry, Institiure for Biophysical Dynamics and the James Franck Institute • The University of Chicago, Chicago, IL
    Research Project:Cell membrane-mediated amyloid-ß fibrillogenesis and neurotoxicity

Ongoing Research Support:

  • Alzheimer's Association New Investigator Research Grant, 07/01/2009 - 06/30/2011
    Lipid membrane mediated tau aggregation and toxicity
  • Oak Ridge Associated Universities Ralph E. Powe Junior Faculty Enhancement Award, 06/01/2009-05/31/2010
    Lipid membrane-templated protein misfolding in Alzheimer's disease
  • University of New Mexico Research Allocation Committee, 01/01/09-12/31/09
    Interaction of tau protein with lipid membrane in the pathogenesis of Alzheimer's disease
  • Air Force Research Laboratory, 09/15/2008-09/14/2009
    Bio/nano architectures for enzyme catalyzed energy conversion
  • Office of Naval Research, 10/01/2009-09/30/2010
    A Comprehensive Facility for Surface Plasmon Resonance Spectroscopy at the University of New Mexico

Selected Publications:

  • L Ding, EY Chi, S Chemburu, E Ji, KS. Schanze, GP Lopez, DG Whitten, Insight into the mechanism of antimicrobial poly(phenylene ethynylene) polyelectrolytes: interactions with phosphatidylglycerol lipid membranes, (2009) Langmuir, Article ASAP
  • MK Ratajczak, EY Chi, SL Frey, KD Cao, LM Luther, K Kjaer, J Majewski, KYC Lee, Ordered nanoclusters in lipid-cholesterol membranes, (2009) Physical Review Letters, 103, 028103
  • PC Stenger, G Wu, CE Miller, EY Chi, SL Frey, KYC. Lee, J Majewski, K Kjaer, JA Zasadzinski, X-Ray diffraction and reflectivity study of the competitive adsorption of lung surfactant and albumin, (2009) Biophysical Journal, in print
  • SL Frey, EY Chi, Arratia C, KYC Lee. Condensing and fluidizing effects of Ganglioside GM1 on phospholipid films, (2008) Biophysical Journal, 94: 3047-3064.
  • EY Chi, C Ege, A Winans, J Majewski, G Wu, K Kjaer, KYC Lee. Lipid membrane templates the ordering and induces the fibrillogenesis of Alzheimer's disease amyloid-beta peptide, (2008) Proteins, 72: 1-24.
  • EY Chi, SL Frey, KYC Lee. Ganglioside GM1-mediated amyloid-beta fibrillogenesis and membrane disruption, (2007) Biochemistry, 46: 1913-24.
  • EY Chi, BS Kendrick, JF Carpenter, TW Randolph. Population balance modeling of aggregation kinetics of recombinant human interleukin-1 receptor antagonist, (2005) Journal of Pharmaceutical Sciences, 94: 2735-2748.
  • EY Chi, J Weickmann, JF Carpenter, MC Manning, TW Randolph. Heterogeneous nucleation controlled intermittent aggregation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation, (2005) Journal of Pharmaceutical Sciences, 94: 256-274.
  • EY Chi, S Krishnan, TW Randolph, JF Carpenter. Physical stability of proteins in aqueous solution: mechanism and driving forces in non-native protein aggregation, (2003) Pharmaceutical Research, 20, 1325-133.

Total Publications in Career:

  • 13 Publications, 30+ Invited Talks, Presentations and Posters

Research Interests

  • Biomolecular engineering
  • Protein interfacial dynamics
  • Protein misfolding and aggregation in human diseases
  • Stability and formulation of therapeutic proteins