Jeffrey Brinker

Contact


Phone: (505)-272-7627

Physical Address

Room 203A
Farris Engineering Center

Photo: true

Professor

Education

Ph.D. Rutgers University Ceramic Science and Engineering.

M.S. Rutgers University Ceramic Science and Engineering.

B.S. Rutgers University Ceramic Science and Engineering.

Biography

Professional Experience

  • 2008 Distinguished Professor of Chemical and Nuclear Engineering and Molecular Genetics and Microbiology • University of New Mexico, Albuquerque, NM.
  • 2006 - Present: Regent's Professor of Chemical and Nuclear Engineering and Molecular Genetics and Microbiology • University of New Mexico, Albuquerque, NM.
  • 2003 - Present: Laboratory Fellow (one of two lab-wide), Sandia National Laboratories (SNL), Albuquerque.
  • 1999 - 2006: Professor of Chemistry and Chemical and Nuclear Engineering • University of New Mexico, Albuquerque, NM.
  • 1999-2003: Senior Scientist, Chemical Synthesis and Nanomaterials Department • Sandia National Laboratories.
  • 1991-99: Distinguished National Laboratory Professor of Chemistry and Chemical and Nuclear Engineerin• University of New Mexico, Albuquerque, NM.
  • 1991-98: Distinguished Member of the Technical Staff, Direct Fabrication Dept • Sandia National Laboratories.
  • 1979-91: Member of the Technical Staff, Chemistry and Ceramics Department • Sandia National Laboratories.

Ongoing Research Support:

  • NIH, Cancer Nanotechnology Platform Partnerships • 9/1/2010 - 8/31/2015
    Peptide-directed Protocells and Virus-Like Particles - new nanoparticle platforms for targeted delivery of multicomponent drugs
    co-PIs: C.L. Willman, MD, UNM Cancer Center; C.J. Brinker, ChNE.
    Our proposed research addresses the full spectrum of challenges underlying nanocarriers as targeted delivery platforms for cancer therapy. It couples unique genomic insight and renowned clinical experience on Acute Lympoblastic Leukemia (ALL) with two new, powerful and versatile targeted nanoparticle delivery systems - protocells (nanoporous nanoparticle supported lipid bilayers) and virus-like particles(VLPs) - each directed with peptides identified by a high complexity VLP affinity selection technology.
  • NIEHS U19 • 10/1/2010 - 9/30/2015
    Center for Nanobiology and Predictive Toxicology
    PI: Andre Nel, MD, UCLA; C.J. Brinker, Key collaborator.
    This center will study how properties of engineered nanomaterials may lead to lung health effects by creating harmful interactions in cells and tissues that will come into contact with these materials. This will be accomplished by a multi-disciplinary team with expertise in nanomaterial science, biology, toxicology, imaging, statistics and computer science to integrate these goals into a predictive model that projects from what is happening in cells to what may happen in the lung.
  • Defense Threat Reduction Agency - DTRA  October 2008-Sept 2011
    Examining the Bio-Nano Interface: Integrating Living Cells into 3D Nanomaterials
    C.J. Brinker, PI
    This project will initiate a detailed study to determine and understand the fundamental nanomaterial and biochemical principles that govern cell-directed self-assembly to enable application of this substantial nanobioscience advancement to mammalian cells.
  • AFOSR • 12/2009 - 11/2012
    Biocompatible and Biomimetic Self-Assembly of Functional Nanostructures
    C.J. Brinker, PI
    Using the methods of cell-directed assembly (CDA) and cell-directed integration (CDI) developed in the Brinker laboratory, we propose the discovery and integration of new classes of hybrid materials and devices displaying a symbiotic relationship between the biotic and abiotic components.


    For listing of additional research click here

Selected Publications:

  • C.E. Ashley, E.C. Carnes, G.K. Phillips, D. Padilla, P.N. Durfee, P.A. Brown, T. N. Hanna, J. Liu, B. Phillips, M.B. Carter, N.J. Carroll, X. Jiang, D.R. Dunphy, C.L. Willman, D.N. Petsev, D.G. Evans, A.N. Parikh, B. Chackerian, W Wharton, D.S. Peabody, and C.J. Brinker. The Targeted Delivery of Multicomponent Cargos to Cancer Cells via Nanoporous Particle-Supported Lipid Bilayers, Nature Materials, Accepted Feb 2011.
  • C.Y. Khripin, D. Pristinski, D.R. Dunphy, C.J. Brinker, and B.J. Kaehr, Protein-Directed Assembly of Arbitrary Three-Dimensional Nanoporous Silica, ACS Nano,5, 1401-1409 2011.
  • Z. Chen, Y.B. Jiang, D.R. Dunphy, D.P. Adams, C. Hodges, N.G. Liu, N. Zhang, G. Xomeritakis, N.R. Aluru, S.J. Gaik, H.W. Hillhouse, and C.J. Brinker, DNA translocation through an array of kinked nanopores, Nature Materials 9 (8) 667-675 Aug 2010.
  • Eric Carnes, DeAnna M Lopez, Niles P Donegan, Ambrose Cheung, Hattie Gresham, Graham Timmins, and C. Jeffrey Brinker, Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria, Nature Chemical Biology, November 2009.
  • Hongyou Fan, Christopher Hartshorn, Thomas Buchheit, David Tallant, Roger Assink, Regina Simpson, Dave J. Kissel, Daniel J. Lacks, Salvatore Torquato, and C. Jeffrey Brinker, Modulus–density scaling behaviour and framework architecture of nanoporous self-assembled silicas, Nature Materials, June 2007, vol. 6, p.418-423.
  • Helen K. Baca, Carlee Ashley, Eric Carnes, Deanna Lopez, Jeb Flemming, Darren Dunphy, Seema Singh, Zhu Chen, Nanguo Liu, Hongyou Fan, Gabriel P. Lopez, Susan M Brozik, Magaret Werner-Washburne, C. Jeffrey Brinker, Cell-Directed Assembly of Lipid-Silica Nanostructures Providing Extended Cell Viability. , Science, Jul 21, 2006; vol. 313, p. 337-341.
  • Yang K, Fan H, O’Brien MJ, La Fontaine S., Lopez GP, Malloy KJ, Brinker CJ, Sigmon TW, Electrical and optical properties of self-assembled, ordered gold nanocrystal/silica thin films prepared by sol-gel processing, Proceedings of the Materials Research Society Micro- and Nanosystems – Materials and Devices 872, 103-108 (2005).
  • Fan H, Yang K, Gabaldon JP, Boye DM, Sigmon TW, Malloy KJ, Brinker CJ, Self-assembly and integration of ordered, robust three-dimensional gold nanocrystal/metal oxide superlattices, Proceedings of NSTI Nanotech 2005, p. 765-768.
  • Kwoun SJ, Cairncross R, Lec RM, Shah P., Brinker C.J. , The Study of interaction of superhydrophobic (SH) materials with fluids using TSM sensors, Proceedings of the 2005 IEEE International, Frequency Control Symposium and Exposition, August 29-31, 2005; p. 78-83.

    For listing of more publication click here

Research Interests

  • Conjugated Polymer Silica Nanocomposites.
  • Photoresponsive nanocomposite membranes for nanovalves.
  • Ion Channel Sensors.
  • Super-hydrophobic surfaces.
  • Nanostructured molecular sieve membranes.
  • Mesoporous Micro- and Nano-particles prepared by Evaporation-Induced Self Assembly within Aerosols.
  • Synthesis and Characterization of Germanium Nanocrystals.
  • Nanoporous silica composite material for corrosion inhibition of aluminum alloys.